So you got a new filament and you want to ensure the best quality print you can for that spool...

Step 1: Ensure your bed is level! Step 2: Ensure your bed is level! Step 3: Calibrate your E-Steps --- You need to ensure your extruding properly Step 4: Gnome_PLA_Temp_Tower --- Pick the best-looking temp Step 5: Gnome_PLA_Retract_Tower --- Pick your best Retraction distance Step 6: Gnome_PLA_Flow_Rate_Cube_0.4mm --- Rob from 3D Printscape does a fantastic job of explaining this process. Step 7: Gnome_PLA_XYZ_Calibration_Cube

I have included both the .stl for those wanting to customize their calibration as well as the .gcode I used for my personal calibration.